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Photo by Claire Bound (@claires.aesthetics.cardiff) · August 29, 2026

Iron levels in the brain significantly increased after TBI, likely due to hemorrhage-induced iron deposition in the brain parenchyma

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The activity of CUL5 is highly dependent on NEDD8-mediated neddylation, and its dysregulation indirectly influences tumor cell proliferation, apoptosis, metabolic reprogramming, angiogenesis, and the immune microenvironment by modulating key signaling pathways such as NOXA, mTORC, TRAF6/NF-κB, and JAK/STAT